| 2022-02-18 18:15:00February 18, 2022 |   Oakleigh Cannons FC vs Green Gully SC | 1 - 2 | U21 NPL VIC | Jack Edwards Reserve - Pitch 2 (S) |
| 2022-02-26 15:00:00February 26, 2022 |  Green Gully SC vs Altona Magic SC | 2 - 3 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-03-05 19:30:00March 5, 2022 |  Port Melbourne Sharks SC vs Green Gully SC | 1 - 1 | U21 NPL VIC | JL Murphy Reserve - SS Anderson Oval - Pitch 1 - (NPL) |
| 2022-03-12 15:00:00March 12, 2022 |  Green Gully SC vs Dandenong City SC | 2 - 0 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-03-19 12:15:00March 19, 2022 |  Avondale FC vs Green Gully SC | 3 - 0 | U21 NPL VIC | Avenger Park |
| 2022-03-26 13:00:00March 26, 2022 |  Green Gully SC vs South Melbourne FC | 1 - 1 | U21 NPL VIC | Ballarat Regional Soccer Facility - Pitch 1 |
| 2022-04-01 18:30:00April 1, 2022 |  Bentleigh Greens SC vs Green Gully SC | 2 - 0 | U21 NPL VIC | Kingston Heath Soccer Complex - Pitch 2 (S) |
| 2022-04-09 15:00:00April 9, 2022 |  Green Gully SC vs Melbourne Knights FC | 0 - 4 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-04-16 12:30:00April 16, 2022 |  St Albans Saints SC vs Green Gully SC | 2 - 3 | U21 NPL VIC | TBC |
| 2022-04-23 15:00:00April 23, 2022 |  Green Gully SC vs Hume City FC | 2 - 4 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-04-30 15:00:00April 30, 2022 |  Green Gully SC vs Heidelberg United FC | 4 - 5 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-05-07 12:15:00May 7, 2022 |  Eastern Lions SC vs Green Gully SC | 1 - 0 | U21 NPL VIC | Gardiners Creek Reserve - Pitch 1 - (NPL) |
| 2022-05-14 15:00:00May 14, 2022 |  Green Gully SC vs Dandenong Thunder FC | 0 - 5 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-05-21 15:00:00May 21, 2022 | Green Gully SC vs Oakleigh Cannons FC | 0 - 2 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-05-28 16:00:00May 28, 2022 | Altona Magic SC vs Green Gully SC | 3 - 0 | U21 NPL VIC | Paisley Park - Pitch 1 - (NPL) |
| 2022-06-04 15:00:00June 4, 2022 | Green Gully SC vs Port Melbourne Sharks SC | 2 - 3 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-06-11 14:45:00June 11, 2022 | Dandenong City SC vs Green Gully SC | 2 - 0 | U21 NPL VIC | Frank Holohan Soccer Complex - Pitch 2 |
| 2022-06-18 15:00:00June 18, 2022 | Green Gully SC vs Avondale FC | 3 - 1 | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-06-25 13:15:00June 25, 2022 | South Melbourne FC vs Green Gully SC | 7 - 1 | U21 NPL VIC | State Football Centre - Pitch 1 (S) |
| 2022-07-02 15:00:00July 2, 2022 | Green Gully SC vs Bentleigh Greens SC | 15:00:003:00 pm | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-07-09 15:00:00July 9, 2022 | Melbourne Knights FC vs Green Gully SC | 15:00:003:00 pm | U21 NPL VIC | Knights Stadium - Pitch 1 |
| 2022-07-16 15:00:00July 16, 2022 | Green Gully SC vs St Albans Saints SC | 15:00:003:00 pm | U21 NPL VIC | Green Gully Reserve - Pitch 1 - (NPL) |
| 2022-07-23 16:00:00July 23, 2022 | Hume City FC vs Green Gully SC | 16:00:004:00 pm | U21 NPL VIC | ABD Stadium Broadmeadows Valley Park - Pitch 1 (NPL) |
South Melbourne FC
Oakleigh Cannons FC
Avondale FC
Hume City FC
Port Melbourne Sharks SC
Bentleigh Greens SC
Altona Magic SC
Dandenong Thunder FC
Eastern Lions SC
Dandenong City SC
Melbourne Knights FC
Heidelberg United FC
St Albans Saints SC
Green Gully SC
